Systematic Literature Review Living SLR Meta-Analysis Evidence Grading Medical Affairs KOL Intelligence Congress Intelligence Medical & Scientific Writing HEOR Market Access Investor & BD Reports Evidence Marketplace Clinical Development Competitive Intelligence Always-on Monitors
Pricing Platform Skills Contact
Sign in Request a Demo
Evidara · Living SLR — Continuous Evidence Monitoring

Your SLR doesn't end
when you publish it.

Living SLR saves your search protocol — PICO, search strings, inclusion criteria — and automatically surfaces new publications matching your evidence question on every check. One setup. Continuous updates. Every new paper sourced and classified the moment it enters PubMed.

Request a Demo → See Full SLR
PICO saved
Full search protocol stored — query, PICO, verbatim search strings, inclusion criteria
Diff on check
New PMIDs since last check automatically identified — only genuinely new papers surfaced
PRISMA ready
Update reports maintain PRISMA flow counts across all monitoring cycles
21 CFR
Audit trail captures each monitoring cycle — date, new PMIDs, human review status
The evidence currency problem

Three reasons your SLR is out
of date before submission.

A systematic literature review that took three months to complete is already obsolete the day it's submitted. The evidence base doesn't stop at the search date — but most SLR workflows do.

01 — Evidence Lag
A three-month SLR has a three-month evidence gap by submission
Between the database lock date for an SLR and the date it's submitted to an HTA body or journal, new RCTs publish, safety signals emerge, and new GRADE-altering evidence appears. Re-running the search manually takes weeks — and often doesn't happen, leaving a known evidence gap in every submission.
Known evidence gap in every HTA submission
02 — Protocol Drift
Re-running a search without the saved protocol introduces inconsistency
When an SLR needs updating, the original search protocol is often in a Word document that's been revised several times, or in a team member's email thread. Re-running with a different query introduces protocol drift — the updated SLR is no longer methodologically consistent with the original, which auditors and reviewers will flag.
Protocol inconsistency between SLR versions
03 — Regulatory Expectation
NICE and EMA expect living review status for rapidly evolving indications
In fast-moving indications — oncology, rare disease, gene therapy — NICE and EMA explicitly expect evidence reviews to be updated regularly. A static SLR submitted for re-assessment after new trial data is a known regulatory risk. Meeting this expectation manually is not scalable.
Regulatory risk in dynamic indications
How Evidara solves it

One SLR run becomes a
continuously updated evidence feed.

Protocol Persistence

Your search protocol stored and versioned

When you run a Full SLR on Evidara, the complete search protocol is automatically stored — PICO framework, verbatim search strings for every database, inclusion and exclusion criteria, and the set of PMIDs retrieved on that run. Every subsequent monitoring check re-uses the exact same protocol, ensuring methodological consistency across updates.
PICO, search strings, and criteria stored per protocol
Protocol versioned — changes logged with timestamp and reason
Verbatim search strings suitable for methods section documentation
Stored in Supabase with 21 CFR Part 11-inspired audit trail
Incremental Diff

Only genuinely new papers surfaced on each check

On each monitoring check, Evidara re-runs the stored PubMed search and diffs the returned PMIDs against all previously seen PMIDs — surfacing only the publications that are genuinely new since the last run. No duplicate review. No re-screening previously excluded papers. Exactly what the reviewer needs to assess.
PMID diff against full historical retrieval set
New papers only — previously seen records excluded
Diff timestamped and logged for audit trail
Zero new papers also recorded — "no new evidence" is a valid result
PRISMA-Consistent Updates

Update reports maintain PRISMA flow across cycles

Each monitoring cycle generates a PRISMA-consistent update report — new records identified, screened, excluded with reason, and included since last check. Cumulative counts are maintained across all cycles so the final submission can report the complete search history with an unbroken PRISMA flow from original run through every update.
PRISMA flow counts maintained per monitoring cycle
Cumulative screening and inclusion counts across all runs
Exclusion reasons documented per screened paper
Human review declaration required before each cycle finalizes
Illustrative example

Riluzole in ALS — living evidence monitor

A Living SLR locks the PICO from a completed Full SLR and re-runs the identical search on a schedule — surfacing only publications not seen before, re-rating certainty when new evidence changes it, and recording every cycle in a PRISMA-consistent update report with a complete audit trail.

Start with a Full SLR →
"Monitor new evidence on riluzole survival outcomes in ALS — PICO locked, check monthly for new publications matching original protocol"
Each cycle reports what is new, by study type, and whether certainty moved
Certainty re-rated per outcome when new evidence changes it, with the reason recorded
Label changes and confirmatory syntheses flagged alongside new publications
Previously seen PMIDs are suppressed so each cycle returns only genuinely new records
Search strings are reused verbatim from the original SLR, so protocol drift is detectable
Living SLR · PubMed monitoring · Illustrative example — not a live analysis · PROVISIONAL, human review required on every cycle before use
Get started

Turn your next SLR into a
living evidence monitor.

Every Full SLR run on Evidara can be saved as a Living SLR protocol. We'll show you how in the demo — including how update reports feed into PRISMA-consistent HTA submissions. Your indication. Your PICO.

Request a Demo → See Full SLR →